Laminin-111 protein therapy after disease onset slows muscle disease in a mouse model of laminin-α2 related congenital muscular dystrophy

Laminin-α2 related congenital muscular dystrophy (LAMA2-CMD) is a fatal muscle disease caused by mutations in the LAMA2 gene. Laminin-α2 is critical for the formation of laminin-211 and -221 heterotrimers in the muscle basal lamina. LAMA2-CMD patients exhibit hypotonia from birth and progressive mus...

Full description

Saved in:
Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Barraza-Flores, Pamela, Bukovec, Katherine E, Dagda, Marisela, Conner, Brandon W, Oliveira-Santos, Ariany, Grange, Robert W, Burkin, Dean J
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
General Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526790/
https://ncbi.nlm.nih.gov/pubmed/32472139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa104
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items