Laminin-111 protein therapy after disease onset slows muscle disease in a mouse model of laminin-α2 related congenital muscular dystrophy

Laminin-α2 related congenital muscular dystrophy (LAMA2-CMD) is a fatal muscle disease caused by mutations in the LAMA2 gene. Laminin-α2 is critical for the formation of laminin-211 and -221 heterotrimers in the muscle basal lamina. LAMA2-CMD patients exhibit hypotonia from birth and progressive mus...

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Udgivet i:Hum Mol Genet
Main Authors: Barraza-Flores, Pamela, Bukovec, Katherine E, Dagda, Marisela, Conner, Brandon W, Oliveira-Santos, Ariany, Grange, Robert W, Burkin, Dean J
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
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General Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526790/
https://ncbi.nlm.nih.gov/pubmed/32472139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa104
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