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Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease caused by mutations in the gene encoding dystrophin. Loss of dystrophin results in reduced sarcolemmal integrity and increased susceptibility to muscle damage. The α(7)β(1)-integrin is a laminin-binding protein up-regulated in...

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書目詳細資料
Main Authors: Rooney, Jachinta E., Gurpur, Praveen B., Burkin, Dean J.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2683113/
https://ncbi.nlm.nih.gov/pubmed/19416897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811599106
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