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A defined structural unit enables de novo design of small-molecule–binding proteins
The de novo design of proteins that bind highly functionalized small molecules represents a great challenge. To enable computational design of binders, we developed a unit of protein structure—a van der Mer (vdM)—that maps the backbone of each amino acid to statistically preferred positions of inter...
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| Pubblicato in: | Science |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7526616/ https://ncbi.nlm.nih.gov/pubmed/32883865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abb8330 |
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