Epigenetic silencing of CD4 expression in nonpathogenic SIV infection in African green monkeys

African green monkeys (AGMs) are natural hosts of SIV that postthymically downregulate CD4 to maintain a large population of CD4(–)CD8aa(+) virus-resistant cells with Th functionality, which can result in AGMs becoming apparently cured of SIV(agm) infection. To understand the mechanisms of this proc...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Mudd, Joseph C., Lai, Stephen, Shah, Sanjana, Rahmberg, Andrew, Flynn, Jacob K., Starke, Carly E., Perkins, Molly R., Ransier, Amy, Darko, Sam, Douek, Daniel C., Hirsch, Vanessa M., Cameron, Mark, Brenchley, Jason M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526541/
https://ncbi.nlm.nih.gov/pubmed/32841214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.139043
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