The evaluation of red blood cell folate and methotrexate levels during protocol M in childhood acute lymphoblastic leukemia

BACKGROUND: After High-Dose Methotrexate (HD-MTX), folinic acid rescue therapy (Leucovorin) is administered to reduce side effects in pediatric acute lymphoblastic leukemia (ALL) patients. Leucovorin and MTX are structural analogues, possibly competing for cellular transport and intracellular metabo...

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Bibliografski detalji
Izdano u:BMC Cancer
Glavni autori: Oosterom, N., Fiocco, M., Kloos, R. Q. H., van der Sluis, I. M., Pieters, R., van Zelst, B. D., Smith, D. E. C., van den Heuvel-Eibrink, M. M., de Jonge, R., Heil, S. G.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526241/
https://ncbi.nlm.nih.gov/pubmed/32998716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07422-y
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