Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia

BACKGROUND: Methotrexate (MTX) is an important anti-folate agent in pediatric acute lymphoblastic leukemia (ALL) treatment. Folinic acid rescue therapy (Leucovorin) is administered after MTX to reduce toxicity. Previous studies hypothesized that Leucovorin could ‘rescue’ both normal healthy cells an...

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Bibliographic Details
Published in:PLoS One
Main Authors: Oosterom, Natanja, de Jonge, Robert, Smith, Desiree E. C., Pieters, Rob, Tissing, Wim J. E., Fiocco, Marta, van Zelst, Bertrand D., van den Heuvel-Eibrink, Marry M., Heil, Sandra G.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748431/
https://ncbi.nlm.nih.gov/pubmed/31527879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0221591
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