Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia

BACKGROUND: Methotrexate (MTX) is an important anti-folate agent in pediatric acute lymphoblastic leukemia (ALL) treatment. Folinic acid rescue therapy (Leucovorin) is administered after MTX to reduce toxicity. Previous studies hypothesized that Leucovorin could ‘rescue’ both normal healthy cells an...

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Udgivet i:PLoS One
Main Authors: Oosterom, Natanja, de Jonge, Robert, Smith, Desiree E. C., Pieters, Rob, Tissing, Wim J. E., Fiocco, Marta, van Zelst, Bertrand D., van den Heuvel-Eibrink, Marry M., Heil, Sandra G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748431/
https://ncbi.nlm.nih.gov/pubmed/31527879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0221591
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