Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia

BACKGROUND: Methotrexate (MTX) is an important anti-folate agent in pediatric acute lymphoblastic leukemia (ALL) treatment. Folinic acid rescue therapy (Leucovorin) is administered after MTX to reduce toxicity. Previous studies hypothesized that Leucovorin could ‘rescue’ both normal healthy cells an...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Oosterom, Natanja, de Jonge, Robert, Smith, Desiree E. C., Pieters, Rob, Tissing, Wim J. E., Fiocco, Marta, van Zelst, Bertrand D., van den Heuvel-Eibrink, Marry M., Heil, Sandra G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2019
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748431/
https://ncbi.nlm.nih.gov/pubmed/31527879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0221591
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk