Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia

BACKGROUND: Children with acute lymphoblastic leukemia (ALL) often suffer from toxicity of chemotherapeutic drugs such as Methotrexate (MTX). Previously, we reported that 20% of patients receiving high-dose MTX developed oral mucositis. MTX inhibits folate metabolism, which is essential for DNA meth...

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Veröffentlicht in:PLoS One
Hauptverfasser: Oosterom, Natanja, Griffioen, Pieter H., den Hoed, Marissa A. H., Pieters, Rob, de Jonge, Robert, Tissing, Wim J. E., van den Heuvel-Eibrink, Marry M., Heil, Sandra G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037363/
https://ncbi.nlm.nih.gov/pubmed/29985926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0199574
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