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The evaluation of red blood cell folate and methotrexate levels during protocol M in childhood acute lymphoblastic leukemia
BACKGROUND: After High-Dose Methotrexate (HD-MTX), folinic acid rescue therapy (Leucovorin) is administered to reduce side effects in pediatric acute lymphoblastic leukemia (ALL) patients. Leucovorin and MTX are structural analogues, possibly competing for cellular transport and intracellular metabo...
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| Veröffentlicht in: | BMC Cancer |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7526241/ https://ncbi.nlm.nih.gov/pubmed/32998716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07422-y |
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