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Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation
The E571K mutation of CRM1 is highly prevalent in some cancers, but its mechanism of tumorigenesis is unclear. Glu571 of CRM1 is located in its nuclear export signal (NES)-binding groove, suggesting that binding of select NESs may be altered. We generated HEK 293 cells with either monoallelic CRM1WT...
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| Izdano u: | Mol Biol Cell |
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| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The American Society for Cell Biology
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7525811/ https://ncbi.nlm.nih.gov/pubmed/32520643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E20-04-0233 |
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