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Structural prerequisites for CRM1-dependent nuclear export signaling peptides: accessibility, adapting conformation, and the stability at the binding site

Nuclear export signal (NES) motifs function as essential regulators of the subcellular location of proteins by interacting with the major nuclear exporter protein, CRM1. Prediction of NES is of great interest in many aspects of research including cancer, but currently available methods, which are mo...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Lee, Yoonji, Pei, Jimin, Baumhardt, Jordan M., Chook, Yuh Min, Grishin, Nick V.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488578/
https://ncbi.nlm.nih.gov/pubmed/31036839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43004-0
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