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Structural determinants of nuclear export signal orientation in binding to exportin CRM1

The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure. The plasticity of the CRM1-NES interaction is not well understood, as there are many...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Fung, Ho Yee Joyce, Fu, Szu-Chin, Brautigam, Chad A, Chook, Yuh Min
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596688/
https://ncbi.nlm.nih.gov/pubmed/26349033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.10034
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