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Atomic basis of CRM1-cargo recognition, release and inhibition
CRM1 or XPO1 is the major nuclear export receptor in the cell, which controls the nuclear-cytoplasmic localization of many proteins and RNAs. CRM1 is also a promising cancer drug target as the transport receptor is overexpressed in many cancers and quite a few of its cargos are misregulated in the d...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4108548/ https://ncbi.nlm.nih.gov/pubmed/24631835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcancer.2014.03.002 |
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