A Myristoyl Amide Derivative of Doxycycline Potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis, Without Retaining Antibiotic Activity

Here, we describe the chemical synthesis and biological activity of a new Doxycycline derivative, designed specifically to more effectively target cancer stem cells (CSCs). In this analog, a myristic acid (14 carbon) moiety is covalently attached to the free amino group of 9-amino-Doxycycline. First...

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Foilsithe in:Front Oncol
Main Authors: Ózsvári, Béla, Magalhães, Luma G., Latimer, Joe, Kangasmetsa, Jussi, Sotgia, Federica, Lisanti, Michael P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2020
Ábhair:
Oncology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523513/
https://ncbi.nlm.nih.gov/pubmed/33042796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.01528
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