A Myristoyl Amide Derivative of Doxycycline Potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis, Without Retaining Antibiotic Activity

Here, we describe the chemical synthesis and biological activity of a new Doxycycline derivative, designed specifically to more effectively target cancer stem cells (CSCs). In this analog, a myristic acid (14 carbon) moiety is covalently attached to the free amino group of 9-amino-Doxycycline. First...

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Main Authors: Béla Ózsvári, Luma G. Magalhães, Joe Latimer, Jussi Kangasmetsa, Federica Sotgia, Michael P. Lisanti
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2020-09-01
叢編:Frontiers in Oncology
主題:
cancer stem-like cells (CSCs)
Doxycycline
myristic acid
fatty acylation
cancer cell metastasis
prophylaxis of metastasis
在線閱讀:https://www.frontiersin.org/article/10.3389/fonc.2020.01528/full
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