Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma

BACKGROUND: Glioblastoma (GBM) has been extensively researched over the last few decades, yet despite aggressive multimodal treatment, recurrence is inevitable and second-line treatment options are limited. Here, we demonstrate how high-throughput screening (HTS) in multicellular spheroids can gener...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Taylor, Jessica T, Ellison, Stuart, Pandele, Alina, Wood, Shaun, Nathan, Erica, Forte, Gabriella, Parker, Helen, Zindy, Egor, Elvin, Mark, Dickson, Alan, Williams, Kaye J, Karabatsou, Konstantina, McCabe, Martin, McBain, Catherine, Bigger, Brian W
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523458/
https://ncbi.nlm.nih.gov/pubmed/32227096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa051
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