Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma

BACKGROUND: Glioblastoma (GBM) has been extensively researched over the last few decades, yet despite aggressive multimodal treatment, recurrence is inevitable and second-line treatment options are limited. Here, we demonstrate how high-throughput screening (HTS) in multicellular spheroids can gener...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Taylor, Jessica T, Ellison, Stuart, Pandele, Alina, Wood, Shaun, Nathan, Erica, Forte, Gabriella, Parker, Helen, Zindy, Egor, Elvin, Mark, Dickson, Alan, Williams, Kaye J, Karabatsou, Konstantina, McCabe, Martin, McBain, Catherine, Bigger, Brian W
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523458/
https://ncbi.nlm.nih.gov/pubmed/32227096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa051
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