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ACTINOMYCIN-D DOWNREGULATES SOX-2 AND REDUCES TUMOUR GROWTH IN A PRE-CLINICAL MODEL OF GLIOBLASTOMA
BACKGROUND: Actinomycin-D (ACTD) is antineoplastic antibiotic and is used to treat a variety of childhood cancers, including neuroblastoma. Few studies have investigated the efficacy of ACTD in high grade glioma; however our 3D-high throughput assay system has identified ACTD to be highly cytotoxic...
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| Publicado no: | Neuro Oncol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6168852/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy129.040 |
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