ACTINOMYCIN-D DOWNREGULATES SOX-2 AND REDUCES TUMOUR GROWTH IN A PRE-CLINICAL MODEL OF GLIOBLASTOMA

BACKGROUND: Actinomycin-D (ACTD) is antineoplastic antibiotic and is used to treat a variety of childhood cancers, including neuroblastoma. Few studies have investigated the efficacy of ACTD in high grade glioma; however our 3D-high throughput assay system has identified ACTD to be highly cytotoxic...

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Publicat a:Neuro Oncol
Autors principals: Taylor, Jessica, Pandele, Alina, Forte, Gabriella, Parker, Helen, Elvin, Mark, Dickson, Alan, Mcbain, Catherine, Bigger, Brian
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168852/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy129.040
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