Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma

BACKGROUND: Glioblastoma (GBM) has been extensively researched over the last few decades, yet despite aggressive multimodal treatment, recurrence is inevitable and second-line treatment options are limited. Here, we demonstrate how high-throughput screening (HTS) in multicellular spheroids can gener...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Taylor, Jessica T, Ellison, Stuart, Pandele, Alina, Wood, Shaun, Nathan, Erica, Forte, Gabriella, Parker, Helen, Zindy, Egor, Elvin, Mark, Dickson, Alan, Williams, Kaye J, Karabatsou, Konstantina, McCabe, Martin, McBain, Catherine, Bigger, Brian W
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523458/
https://ncbi.nlm.nih.gov/pubmed/32227096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa051
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