Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma

BACKGROUND: Glioblastoma (GBM) has been extensively researched over the last few decades, yet despite aggressive multimodal treatment, recurrence is inevitable and second-line treatment options are limited. Here, we demonstrate how high-throughput screening (HTS) in multicellular spheroids can gener...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Neuro Oncol
मुख्य लेखकों: Taylor, Jessica T, Ellison, Stuart, Pandele, Alina, Wood, Shaun, Nathan, Erica, Forte, Gabriella, Parker, Helen, Zindy, Egor, Elvin, Mark, Dickson, Alan, Williams, Kaye J, Karabatsou, Konstantina, McCabe, Martin, McBain, Catherine, Bigger, Brian W
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2020
विषय:
Basic and Translational Investigations
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523458/
https://ncbi.nlm.nih.gov/pubmed/32227096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa051
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