A phase I study of a dual PI3-kinase/mTOR inhibitor BEZ235 in adult patients with relapsed or refractory acute leukemia

BACKGROUND: Combined inhibition of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) complexes may be an efficient treatment for acute leukemia. The primary objective of this phase I single center open label study was to determine the maximum tolerated dose (MTD) and...

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Библиографические подробности
Опубликовано в: :BMC Pharmacol Toxicol
Главные авторы: Lang, Fabian, Wunderle, Lydia, Badura, Susanne, Schleyer, Eberhard, Brüggemann, Monika, Serve, Hubert, Schnittger, Susanne, Gökbuget, Nicola, Pfeifer, Heike, Wagner, Sebastian, Ashelford, Kevin, Bug, Gesine, Ottmann, Oliver G.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2020
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523358/
https://ncbi.nlm.nih.gov/pubmed/32993794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-020-00446-x
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