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RAD001 Enhances the Potency of BEZ235 to Inhibit mTOR Signaling and Tumor Growth
The mammalian target of rapamycin (mTOR) is regulated by oncogenic growth factor signals and plays a pivotal role in controlling cellular metabolism, growth and survival. Everolimus (RAD001) is an allosteric mTOR inhibitor that has shown marked efficacy in certain cancers but is unable to completely...
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| Hoofdauteurs: | , , , , , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3498278/ https://ncbi.nlm.nih.gov/pubmed/23155392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048548 |
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