RAD001 Enhances the Potency of BEZ235 to Inhibit mTOR Signaling and Tumor Growth

The mammalian target of rapamycin (mTOR) is regulated by oncogenic growth factor signals and plays a pivotal role in controlling cellular metabolism, growth and survival. Everolimus (RAD001) is an allosteric mTOR inhibitor that has shown marked efficacy in certain cancers but is unable to completely...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Nyfeler, Beat, Chen, Yan, Li, Xiaoyan, Pinzon-Ortiz, Maria, Wang, Zuncai, Reddy, Anupama, Pradhan, Elina, Das, Rita, Lehár, Joseph, Schlegel, Robert, Finan, Peter M., Cao, Z. Alexander, Murphy, Leon O., Huang, Alan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498278/
https://ncbi.nlm.nih.gov/pubmed/23155392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048548
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items