AMPK promotes SPOP-mediated NANOG degradation to regulate prostate cancer cell stemness

NANOG is an essential transcriptional factor for the maintenance of embryonic stem cells (ESCs) and cancer stem-like cells (CSCs) in prostate cancer (PCa). However, the regulation mechanism of NANOG protein stability in cancer progression is still elusive. Here, we report that NANOG is degraded by S...

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Pubblicato in:Dev Cell
Autori principali: Wang, Xinbo, Jin, Jiali, Wan, Fangning, Zhao, Linlin, Chu, Hongshang, Chen, Cong, Liao, Guanghong, Liu, Jian, Yu, Yue, Teng, Hongqi, Fang, Lan, Jiang, Cong, Pan, Weijuan, Xie, Xin, Li, Jia, Lu, Xiaolin, Jiang, Xuejun, Ge, Xin, Ye, Dingwei, Wang, Ping
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523188/
https://ncbi.nlm.nih.gov/pubmed/30595535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.11.033
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