The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog

Nanog is a master pluripotency factor of embryonic stem cells (ESCs). Stable expression of Nanog is essential to maintain the stemness of ESCs. However, Nanog is a short-lived protein and quickly degraded by the ubiquitin-dependent proteasome system. Here we report that the deubiquitinase USP21 inte...

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Publicado no:Nat Commun
Main Authors: Jin, Jiali, Liu, Jian, Chen, Cong, Liu, Zhenping, Jiang, Cong, Chu, Hongshang, Pan, Weijuan, Wang, Xinbo, Zhang, Lingqiang, Li, Bin, Jiang, Cizhong, Ge, Xin, Xie, Xin, Wang, Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133637/
https://ncbi.nlm.nih.gov/pubmed/27886188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13594
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