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USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency
The homeobox transcription factor Nanog has a vital role in maintaining pluripotency and self-renewal of embryonic stem cells (ESCs). Stabilization of Nanog proteins is essential for ESCs. The ubiquitin–proteasome pathway mediated by E3 ubiquitin ligases and deubiquitylases is one of the key ways to...
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| Publicado no: | Signal Transduct Target Ther |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5661642/ https://ncbi.nlm.nih.gov/pubmed/29263902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sigtrans.2016.24 |
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