USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency

The homeobox transcription factor Nanog has a vital role in maintaining pluripotency and self-renewal of embryonic stem cells (ESCs). Stabilization of Nanog proteins is essential for ESCs. The ubiquitin–proteasome pathway mediated by E3 ubiquitin ligases and deubiquitylases is one of the key ways to...

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Detalles Bibliográficos
Publicado en:Signal Transduct Target Ther
Main Authors: Liu, Xingyu, Yao, Yuying, Ding, Huiguo, Han, Chuanchun, Chen, Yuhan, Zhang, Yuan, Wang, Chanjuan, Zhang, Xin, Zhang, Yiling, Zhai, Yun, Wang, Ping, Wei, Wenyi, Zhang, Jing, Zhang, Lingqiang
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661642/
https://ncbi.nlm.nih.gov/pubmed/29263902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sigtrans.2016.24
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