Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses

p21(WAF1/CIP1) is a broad-acting cyclin-dependent kinase inhibitor. Its stability is essential for proper cell-cycle progression and cell fate decision. Ubiquitylation by the multiple E3 ubiquitin ligase complexes is the major regulatory mechanism of p21, which induces p21 degradation. However, it i...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Deng, Tanggang, Yan, Guobei, Song, Xin, Xie, Lin, Zhou, Yu, Li, Jianglin, Hu, Xiaoxiao, Li, Zhen, Hu, Jun, Zhang, Yibin, Zhang, Hui, Sun, Yang, Feng, Peifu, Wei, Dong, Hu, Bin, Liu, Jing, Tan, Weihong, Ye, Mao
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939064/
https://ncbi.nlm.nih.gov/pubmed/29666278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714938115
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