Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses

p21(WAF1/CIP1) is a broad-acting cyclin-dependent kinase inhibitor. Its stability is essential for proper cell-cycle progression and cell fate decision. Ubiquitylation by the multiple E3 ubiquitin ligase complexes is the major regulatory mechanism of p21, which induces p21 degradation. However, it i...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Deng, Tanggang, Yan, Guobei, Song, Xin, Xie, Lin, Zhou, Yu, Li, Jianglin, Hu, Xiaoxiao, Li, Zhen, Hu, Jun, Zhang, Yibin, Zhang, Hui, Sun, Yang, Feng, Peifu, Wei, Dong, Hu, Bin, Liu, Jing, Tan, Weihong, Ye, Mao
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2018
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939064/
https://ncbi.nlm.nih.gov/pubmed/29666278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714938115
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia