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USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5

Embryonic stem cells (ESCs) can propagate in an undifferentiated state indefinitely in culture and retain the potential to differentiate into any somatic lineage as well as germ cells. The catabolic process autophagy has been reported to be involved in ESC identity regulation, but the underlying mec...

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Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Gu, Haifeng, Shi, Xingxing, Liu, Chao, Wang, Chaoqun, Sui, Ning, Zhao, Yu, Gong, Jiaqi, Wang, Fuping, Zhang, Hong, Li, Wei, Zhao, Tongbiao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443784/
https://ncbi.nlm.nih.gov/pubmed/30931944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09430-4
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