USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5

Embryonic stem cells (ESCs) can propagate in an undifferentiated state indefinitely in culture and retain the potential to differentiate into any somatic lineage as well as germ cells. The catabolic process autophagy has been reported to be involved in ESC identity regulation, but the underlying mec...

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Publicat a:Nat Commun
Autors principals: Gu, Haifeng, Shi, Xingxing, Liu, Chao, Wang, Chaoqun, Sui, Ning, Zhao, Yu, Gong, Jiaqi, Wang, Fuping, Zhang, Hong, Li, Wei, Zhao, Tongbiao
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6443784/
https://ncbi.nlm.nih.gov/pubmed/30931944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09430-4
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