The functional significance of redox-mediated intersubunit cross-linking in regulation of human type 2 ryanodine receptor

The type 2 ryanodine receptor (RyR2) plays a key role in the cardiac intracellular calcium (Ca(2+)) regulation. We have previously shown that oxidative stress activates RyR2 in rabbit cardiomyocytes by promoting the formation of disulfide bonds between neighboring RyR2 subunits. However, the functio...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Nikolaienko, Roman, Bovo, Elisa, Rebbeck, Robyn T., Kahn, Daniel, Thomas, David D., Cornea, Razvan L., Zima, Aleksey V.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7522892/
https://ncbi.nlm.nih.gov/pubmed/32980662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101729
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