Structural analysis of the LDL receptor–interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site

Hepatic abundance of the low-density lipoprotein receptor (LDLR) is a critical determinant of circulating plasma LDL cholesterol levels and hence development of coronary artery disease. The sterol-responsive E3 ubiquitin ligase inducible degrader of the LDLR (IDOL) specifically promotes ubiquitinati...

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Foilsithe in:J Biol Chem
Main Authors: Martinelli, Luca, Adamopoulos, Athanassios, Johansson, Patrik, Wan, Paul T., Gunnarsson, Jenny, Guo, Hongwei, Boyd, Helen, Zelcer, Noam, Sixma, Titia K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2020
Ábhair:
Protein Structure and Folding
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7521653/
https://ncbi.nlm.nih.gov/pubmed/32727844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014349
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