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The therapeutic effect of the BRD4-degrading PROTAC A1874 in human colon cancer cells
A1874 is a novel BRD4-degrading proteolysis targeting chimera (PROTAC). In primary colon cancer cells and established HCT116 cells, A1874 potently inhibited cell viability, proliferation, cell cycle progression, as well as cell migration and invasion. The BRD4-degrading PROTAC was able to induce cas...
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| Publicado no: | Cell Death Dis |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7519683/ https://ncbi.nlm.nih.gov/pubmed/32978368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03015-6 |
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