Recruitment of Brd3 and Brd4 to acetylated chromatin is essential for proinflammatory cytokine-induced matrix-degrading enzyme expression

BACKGROUND: Proinflammatory cytokines, which can upregulate the expression of matrix-degrading enzymes in chondrocytes, play important roles in the development of osteoarthritis. BET family proteins, acting as the “readers” of acetylated modifications on histones, have been linked to transcriptional...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Orthop Surg Res
Main Authors: Dai, Jin, Zhou, Sheng, Ge, Qiting, Qin, Jinzhong, Li, Jianxin, Ju, Huangxian, Cao, Yi, Zheng, Minghao, Li, Chaojun, Gao, Xiang, Teng, Huajian, Jiang, Qing
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381721/
https://ncbi.nlm.nih.gov/pubmed/30786900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13018-019-1091-3
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