Bi-directional regulation of cartilage metabolism by inhibiting BET proteins—analysis of the effect of I-BET151 on human chondrocytes and murine joints

BACKGROUND: Proinflammatory cytokines, which can upregulate the expression of matrix-degrading enzymes in chondrocytes, play important roles in the development of osteoarthritis. And a BET protein inhibitor, I-BET151, has been shown to exert an anti-inflammatory effect by repressing the BET protein-...

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Detalhes bibliográficos
Publicado no:J Orthop Surg Res
Main Authors: Dai, Jin, Zhou, Sheng, Ge, Qiting, Qin, Jinzhong, Chen, Dongyang, Xu, Zhihong, Shi, Dongquan, Li, Jianxin, Ju, Huangxian, Cao, Yi, Zheng, Minghao, Li, Chao Jun, Gao, Xiang, Teng, Huajian, Jiang, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963048/
https://ncbi.nlm.nih.gov/pubmed/29784003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13018-018-0797-y
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