AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice

Osteoarthritis (OA) is a progressive degenerative disease of the joints that is associated with both joint injury and ageing. Here, we investigated the role of the energy sensor AMP-activated protein kinase (AMPK) in maintaining a healthy state of articular cartilage and in OA development. Using car...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhou, Sheng, Lu, Wanli, Chen, Liang, Ge, Qiting, Chen, Dongyang, Xu, Zhihong, Shi, Dongquan, Dai, Jin, Li, Jianxin, Ju, Huangxian, Cao, Yi, Qin, Jinzhong, Chen, Shuai, Teng, Huajian, Jiang, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320548/
https://ncbi.nlm.nih.gov/pubmed/28225087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43245
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