Characterization of BRCA1-deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor

Single-cell whole-exome sequencing (scWES) is a powerful approach for deciphering intratumor heterogeneity and identifying cancer drivers. So far, however, simultaneous analysis of single nucleotide variants (SNVs) and copy number variations (CNVs) of a single cell has been challenging. By analyzing...

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Pubblicato in:Nat Commun
Autori principali: Liu, Jianlin, Adhav, Ragini, Miao, Kai, Su, Sek Man, Mo, Lihua, Chan, Un In, Zhang, Xin, Xu, Jun, Li, Jianjie, Shu, Xiaodong, Zeng, Jianming, Zhang, Xu, Lyu, Xueying, Pardeshi, Lakhansing, Tan, Kaeling, Sun, Heng, Wong, Koon Ho, Deng, Chuxia, Xu, Xiaoling
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519681/
https://ncbi.nlm.nih.gov/pubmed/32978388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18637-9
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