NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation

BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer (TNBC), which is a refractory disease due to its non-responsiveness to current clinical targeted therapies. Using the Sleeping Beauty transposon system in Brca1-deficient mice, we identified 169 putative cancer dr...

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Publicat a:Nat Commun
Autors principals: Miao, Kai, Lei, Josh Haipeng, Valecha, Monica Vishnu, Zhang, Aiping, Xu, Jun, Wang, Lijian, Lyu, Xueying, Chen, Si, Miao, Zhengqiang, Zhang, Xin, Su, Sek Man, Shao, Fangyuan, Rajendran, Barani Kumar, Bao, Jiaolin, Zeng, Jianming, Sun, Heng, Chen, Ping, Tan, Kaeling, Chen, Qiang, Wong, Koon Ho, Xu, Xiaoling, Deng, Chu-Xia
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7320176/
https://ncbi.nlm.nih.gov/pubmed/32591500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16936-9
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