NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation

BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer (TNBC), which is a refractory disease due to its non-responsiveness to current clinical targeted therapies. Using the Sleeping Beauty transposon system in Brca1-deficient mice, we identified 169 putative cancer dr...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Miao, Kai, Lei, Josh Haipeng, Valecha, Monica Vishnu, Zhang, Aiping, Xu, Jun, Wang, Lijian, Lyu, Xueying, Chen, Si, Miao, Zhengqiang, Zhang, Xin, Su, Sek Man, Shao, Fangyuan, Rajendran, Barani Kumar, Bao, Jiaolin, Zeng, Jianming, Sun, Heng, Chen, Ping, Tan, Kaeling, Chen, Qiang, Wong, Koon Ho, Xu, Xiaoling, Deng, Chu-Xia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7320176/
https://ncbi.nlm.nih.gov/pubmed/32591500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16936-9
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