BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1–MCM2 signaling during pregnancy

The mammary gland undergoes fast cell proliferation during early pregnancy, yet the mechanism to ensure genome integrity during this highly proliferative stage is largely unknown. We show that pregnancy triggers replicative stresses leading to genetic instability in mice carrying a mammary specific...

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Détails bibliographiques
Publié dans:Hum Mol Genet
Auteurs principaux: Xu, Xiaoling, Chen, Eric, Mo, Lihua, Zhang, Lei, Shao, Fangyuan, Miao, Kai, Liu, Jianlin, Su, Sek Man, Valecha, Monica, Chan, Un In, Zheng, Hongping, Chen, Mark, Chen, Weiping, Chen, Qiang, Fu, Haiqing, Aladjem, Mirit I, He, Yanzhen, Deng, Chu-Xia
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
General Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381318/
https://ncbi.nlm.nih.gov/pubmed/30445628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy398
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