BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1–MCM2 signaling during pregnancy

The mammary gland undergoes fast cell proliferation during early pregnancy, yet the mechanism to ensure genome integrity during this highly proliferative stage is largely unknown. We show that pregnancy triggers replicative stresses leading to genetic instability in mice carrying a mammary specific...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Xu, Xiaoling, Chen, Eric, Mo, Lihua, Zhang, Lei, Shao, Fangyuan, Miao, Kai, Liu, Jianlin, Su, Sek Man, Valecha, Monica, Chan, Un In, Zheng, Hongping, Chen, Mark, Chen, Weiping, Chen, Qiang, Fu, Haiqing, Aladjem, Mirit I, He, Yanzhen, Deng, Chu-Xia
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
General Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381318/
https://ncbi.nlm.nih.gov/pubmed/30445628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy398
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