HDAC3 deacetylates the DNA mismatch repair factor MutSβ to stimulate triplet repeat expansions

Trinucleotide repeat (TNR) expansions cause nearly 20 severe human neurological diseases which are currently untreatable. For some of these diseases, ongoing somatic expansions accelerate disease progression and may influence age of onset. This new knowledge emphasizes the importance of understandin...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Williams, Gregory M., Paschalis, Vasileios, Ortega, Janice, Muskett, Frederick W., Hodgkinson, James T., Li, Guo-Min, Schwabe, John W. R., Lahue, Robert S.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519323/
https://ncbi.nlm.nih.gov/pubmed/32900932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013223117
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