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HDAC3 deacetylates the DNA mismatch repair factor MutSβ to stimulate triplet repeat expansions
Trinucleotide repeat (TNR) expansions cause nearly 20 severe human neurological diseases which are currently untreatable. For some of these diseases, ongoing somatic expansions accelerate disease progression and may influence age of onset. This new knowledge emphasizes the importance of understandin...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7519323/ https://ncbi.nlm.nih.gov/pubmed/32900932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013223117 |
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