HDAC3 deacetylates the DNA mismatch repair factor MutSβ to stimulate triplet repeat expansions

Trinucleotide repeat (TNR) expansions cause nearly 20 severe human neurological diseases which are currently untreatable. For some of these diseases, ongoing somatic expansions accelerate disease progression and may influence age of onset. This new knowledge emphasizes the importance of understandin...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Williams, Gregory M., Paschalis, Vasileios, Ortega, Janice, Muskett, Frederick W., Hodgkinson, James T., Li, Guo-Min, Schwabe, John W. R., Lahue, Robert S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519323/
https://ncbi.nlm.nih.gov/pubmed/32900932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013223117
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