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DNA Mismatch Repair Complex MutSβ Promotes GAA·TTC Repeat Expansion in Human Cells
While DNA repair has been implicated in CAG·CTG repeat expansion, its role in the GAA·TTC expansion of Friedreich ataxia (FRDA) is less clear. We have developed a human cellular model that recapitulates the DNA repeat expansion found in FRDA patient tissues. In this model, GAA·TTC repeats expand inc...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3436174/ https://ncbi.nlm.nih.gov/pubmed/22787155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.356758 |
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