AR420626, a selective agonist of GPR41/FFA3, suppresses growth of hepatocellular carcinoma cells by inducing apoptosis via HDAC inhibition

BACKGROUND: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide and establishment of new chemotherapies for HCC is urgently needed. GPR41 [free fatty acid receptor 3 (FFA3)] is a G protein-coupled receptor for short chain fatty acids, including acetate, propionate, and butyrate...

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Bibliographic Details
Published in:Ther Adv Med Oncol
Main Authors: Mikami, Daisuke, Kobayashi, Mamiko, Uwada, Junsuke, Yazawa, Takashi, Kamiyama, Kazuko, Nishimori, Kazuhisa, Nishikawa, Yudai, Nishikawa, Sho, Yokoi, Seiji, Taniguchi, Takanobu, Iwano, Masayuki
Format: Artigo
Language:Inglês
Published: SAGE Publications 2020
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7517987/
https://ncbi.nlm.nih.gov/pubmed/33014144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835920913432
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