A short-chain fatty acid, propionate, enhances the cytotoxic effect of cisplatin by modulating GPR41 signaling pathways in HepG2 cells

Short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate are generated by microbial fermentation of indigestible fiber by gut flora. SCFAs are ligands of two orphan G protein-coupled receptors, GPR41 and GPR43, that modulate cell proliferation and induce apoptosis. However, it is un...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Kobayashi, Mamiko, Mikami, Daisuke, Uwada, Junsuke, Yazawa, Takashi, Kamiyama, Kazuko, Kimura, Hideki, Taniguchi, Takanobu, Iwano, Masayuki
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6101142/
https://ncbi.nlm.nih.gov/pubmed/30140374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25809
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