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Therapeutic Potential of Targeting Malt1-Dependent TCR Downstream Signaling to Promote the Survival of MHC-Mismatched Allografts

Strategies targeting T cells are the cornerstone of immunosuppression after solid organ transplantation. The transcription factor NF-κB is a key regulator of downstream T-cell activation and induction of inflammatory mediators; its full activation via antigen receptor engagement requires both the sc...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Govender, Lerisa, Mikulic, Josip, Wyss, Jean-Christophe, Gaide, Olivier, Thome, Margot, Golshayan, Dela
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7517581/
https://ncbi.nlm.nih.gov/pubmed/33042160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.576651
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