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Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity
The protease activity of the paracaspase Malt1 has recently gained interest as a drug target for immunomodulation and the treatment of diffuse large B-cell lymphomas. To address the consequences of Malt1 protease inactivation on the immune response in vivo, we generated knock-in mice expressing a ca...
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| Publicado no: | EMBO J |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4282555/ https://ncbi.nlm.nih.gov/pubmed/25319413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488987 |
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