Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity

The protease activity of the paracaspase Malt1 has recently gained interest as a drug target for immunomodulation and the treatment of diffuse large B-cell lymphomas. To address the consequences of Malt1 protease inactivation on the immune response in vivo, we generated knock-in mice expressing a ca...

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Dades bibliogràfiques
Publicat a:EMBO J
Autors principals: Jaworski, Maike, Marsland, Ben J, Gehrig, Jasmine, Held, Werner, Favre, Stéphanie, Luther, Sanjiv A, Perroud, Mai, Golshayan, Déla, Gaide, Olivier, Thome, Margot
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282555/
https://ncbi.nlm.nih.gov/pubmed/25319413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488987
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