Increased Protein Stability and Interleukin-2 Production of a LAT(G131D) Variant With Possible Implications for T Cell Anergy

The adaptor LAT plays a crucial role in the transduction of signals coming from the TCR/CD3 complex. Phosphorylation of some of its tyrosines generates recruitment sites for other cytosolic signaling molecules. Tyrosine 132 in human LAT is essential for PLC-γ activation and calcium influx generation...

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Bibliographische Detailangaben
Veröffentlicht in:Front Cell Dev Biol
Hauptverfasser: Arbulo-Echevarria, Mikel M., Vico-Barranco, Inmaculada, Narbona-Sánchez, Isaac, García-Cózar, Francisco, Miazek, Arkadiusz, Aguado, Enrique
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Cell and Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7517355/
https://ncbi.nlm.nih.gov/pubmed/33042995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.561503
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