Structural insight into the binding of human galectins to corneal keratan sulfate, its desulfated form and related saccharides

Glycosaminoglycan chains of keratan sulfate proteoglycans appear to be physiologically significant by pairing with tissue lectins. Here, we used NMR spectroscopy and molecular dynamics (MD) simulations to characterize interactions of corneal keratan sulfate (KS), its desulfated form, as well as di-,...

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Vydáno v:Sci Rep
Hlavní autoři: Miller, Michelle C., Cai, Chao, Wichapong, Kanin, Bhaduri, Sayantan, Pohl, Nicola L. B., Linhardt, Robert J., Gabius, Hans-Joachim, Mayo, Kevin H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515912/
https://ncbi.nlm.nih.gov/pubmed/32973213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72645-9
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