Structural insight into the binding of human galectins to corneal keratan sulfate, its desulfated form and related saccharides

Glycosaminoglycan chains of keratan sulfate proteoglycans appear to be physiologically significant by pairing with tissue lectins. Here, we used NMR spectroscopy and molecular dynamics (MD) simulations to characterize interactions of corneal keratan sulfate (KS), its desulfated form, as well as di-,...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Miller, Michelle C., Cai, Chao, Wichapong, Kanin, Bhaduri, Sayantan, Pohl, Nicola L. B., Linhardt, Robert J., Gabius, Hans-Joachim, Mayo, Kevin H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515912/
https://ncbi.nlm.nih.gov/pubmed/32973213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72645-9
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