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Inferring efficiency of translation initiation and elongation from ribosome profiling

One of the main goals of ribosome profiling is to quantify the rate of protein synthesis at the level of translation. Here, we develop a method for inferring translation elongation kinetics from ribosome profiling data using recent advances in mathematical modelling of mRNA translation. Our method d...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Szavits-Nossan, Juraj, Ciandrini, Luca
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7515720/
https://ncbi.nlm.nih.gov/pubmed/32821926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa678
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